Postdoctoral Clinical Fellow

Project Overview

Cancer is a complex disease affecting both local and systemic environments. Our lab investigates cancer’s impact on whole-body function, particularly the cardiovascular, immune, and haematopoietic system. Cancer patients face heightened risks of cardiovascular disease; for instance, lung cancer patients have a 90% increased risk of coronary artery disease, but we still lack information on how this takes place and, most importantly, on how can we protect cancer patients and cancer survivors from this burden.

Tumours also disrupt bone marrow processes and shift the production of different immune cells towards states that favour the growth and dissemination of the tumour. These changes can also cause other problems, including some that will affect cardiovascular health. Understanding how this takes place to find ways to revert it is another goal of the lab. Additionally, tumours influence neutrophils – the most abundant immune cell in human circulation – in ways that favour tumour progression. We are investigating how these cancer-imposed neutrophil changes affect both cancer progression and the general welfare of cancer patients and survivors and, importantly, we are investigating therapeutic approaches to target neutrophils in cancer patients.

All these areas are highly relevant to human disease. Clinicians who are interested in the systemic effects of cancer, cardio-oncology, cancer immunology, cancer-related thrombosis, cancer progression, or in developing novel therapeutic options for cancer patients are welcome to discuss ideas and potential projects.

Lab & Supervisor

Research opportunity in Jose M. Adrover’s lab at [Employer hidden — sign up to reveal], within the Cancer Macroenvironment Lab.