Development of novel microbiome-based strategies for biocontrol of C. difficile (NARBAD_Q22MMB)

Project Overview

Clostridioides difficile is the most common cause of hospital-acquired life-threatening infections. This project aims to develop a cocktail of bacteriophages or bacterial metabolites as a defined treatment to modulate the gut microbiome, offering a safer alternative to faecal transplantation. The student will be based in Prof Narbad's group at [Employer hidden] and work closely with Dr Adriaenssens, in collaboration with The Functional Gut Clinic in Cambridge.

Key Responsibilities

• Develop bacteriophage or metabolite cocktails for C. difficile biocontrol
• Perform anaerobic microbiology and metabolomics experiments
• Conduct gut microbiome bioinformatics and virome metagenomics analysis
• Optimize formulations for future human trials
• Undertake a placement (3-18 months) with the industry partner The Functional Gut Clinic

Requirements

• Undergraduate degree relevant to microbiology, bioinformatics, or related field
• Aptitude for computer-based analysis and curiosity
• Commitment to interdisciplinary research

Training and Support

The MMB DTP offers comprehensive training in microbial bioinformatics, professional development, and research skills. The student will gain skills in gut microbiome bioinformatics, anaerobic microbiology, and metabolomics.

How to Apply

View the MMB webpage for eligibility and application details. Applications close 17 January 2022. Interviews: 15-16 February 2022. Apply via the UEA application link.

Equality and Diversity

The MMB DTP is committed to equality, diversity, widening participation and inclusion. We welcome applications from all sections of the community, including low- and middle-income countries.