The interplay of dietary polyphenols and gut microbiota in mammary tumourigenesis and metastasis (PhD Studentship)
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The interplay of dietary polyphenols and gut microbiota in mammary tumourigenesis and metastasis (PhD Studentship)
[Employer hidden — view at passion-project.co.uk] is seeking a PhD student to investigate the role of dietary polyphenols and gut microbiota in breast cancer. This is a 3-year studentship funded by Norfolk Cancer Charity BIG C. The project involves mouse models, microbiology, immunology, and bioinformatics.
Project Objectives
- Evaluation of the impact of polyphenol-enriched tomato diets on mammary cancer development and metastasis in mice.
- Investigation of changes in gut microbiota in tumour-bearing versus control mice on different diets.
- Evaluation of effects of diets on systemic immunomodulatory factors and immune cell repertoires in tumours.
Training
The project is multi-disciplinary and students will receive training in microbiology, in vivo mouse tumour models, immunology, bioinformatics and mathematical modelling approaches to understand how diet-induced changes in the microbiota affect breast cancer progression and tumour immune surveillance.
Funding Notes
This project is awarded with a 3-year Norfolk Cancer Charity BIG C PhD studentship. Tuition fees are covered for UK/EU rate only (£4,327.00 2019/20 rate). Students liable for international tuition fees will need to fund the difference between the UK/EU fee level and the international fee level (£18,700. 2019/20 rate). A stipend will be provided for each year of the studentship (2019/20 rate is £15,009.00). Research training support funding is available.
How to Apply
Applications close 28 March 2019. Apply via the Quadram Institute student opportunities page: https://quadram.ac.uk/about/student-opportunities/how-to-apply/