Computational Biologist
SKILLS
FULL DESCRIPTION
Computational Biologist
[Employer hidden — view at passion-project.co.uk], Norwich, UK | £31,250 - £38,100 per annum | Contract (2 years)
Background
Dr Jo Dicks at the [Employer hidden] and Dr Robert Davey at the neighbouring Earlham Institute have been instrumental in the development of a dynamic computational research program precisely characterizing ribosomal DNA (rDNA) variation and evolution in yeast, with associated publications in leading journals such as Nature, Genome Research, Systematic Biology and Bioinformatics. The rDNA is fundamental to life, encoding elements involved in the translation of mRNA molecules to proteins. This exciting research program is now poised to begin a new phase of research, investigating rDNA variation and expression across disparate chromosomes in yeast and wheat.
The Role
The successful post holder will develop computer software to predict rDNA sequence and copy number variation from bespoke single chromosome datasets developed in collaboration with Dr Jane Usher at the University of Exeter, using computational techniques such as variation graphs and machine learning. This will be followed by analysis of the discovered variation to enable inferences about the biological processes driving rDNA evolution to be made. Project software will ultimately be used to predict rDNA variation associated with key biological processes such as disease status and healthy ageing. The close collaboration with the Davey group at EI will also provide opportunities to work amongst computational biology groups researching a wider range of projects.
The Ideal Candidate
Candidates are expected to have a PhD in a numerical discipline such as Computational Biology, Bioinformatics, Computer Science or Mathematics. Excellent computer programming skills are also required, with experience in C++ an advantage. Experience in one or more of analysis of genomic and transcriptomic datasets, algorithm design, machine learning and variation graphs would also be highly advantageous. The ability to handle complex concepts and ideas and to work independently are required, as are effective communication skills.
Additional Information
Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of two years.
Application Instructions
For further information and details of how to apply can be found here or contact the Human Resources team on [contact hidden] or [contact hidden] quoting reference 1003395. We are committed to equal opportunities and welcome applications from all sectors of society. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.