Research Associate

About the role

The Matthews Lab invites applications from talented, highly motivated and creative postdoctoral scientists to take a leading role to investigate the molecular neuropathology of Alzheimer’s disease based on the study of post-mortem human tissues.

What you would be doing

You will lead a project intended to develop a molecular description of how glial cells may trigger neurodegeneration in Alzheimer’s disease.  The work will be guided by explorations of how risk variants associated the disease that are expected to modulate microglial function, lipid homeostasis or pathological protein degradation lead potentiate neurodegenerative processes.  A strong foundation for this work has been established with the development of methods for highly multiplexed imaging mass cytometry, multi-omic data acquisition and analyses.

What we are looking for

You will be a motivated and organised researcher, excited by the science we do. You will hold (or be near completion of) a PhD in neuroscience (or related discipline). Experience of one or more laboratory techniques including immunohistology, single cell transcriptomics, spatial transcriptomics Experience of statistical analysis Experience of emerging genomics approaches, e.g., long-read sequencing